aoa体育Erwinase® (crisantaspase) is an L-asparaginase enzyme derived from the bacterium 欧文氏菌Chrysanthemi that is indicated for the treatment of Acute Lymphoblastic Leukaemia (ALL) a type of cancer that particularly affects children.
PBL于20世纪60年代在aoa体育开发,仍然是Erwinase®的唯一全球制造商,Erwinase®于1985年首次在英国注册为产品名称。 从那时起,它已被供应给世界上许多国家的患者治疗。
在英国生产和许可的Erwinase®(Crisantaspase) (PL44403/0002)的供应可通过Clinigen订购
If you are a healthcare professional, please report adverse events to porton.pv@tepsivo.com.
For any other medical information query, please contact us at medinfo@portonbiopharma.com.
Since announcing a new exclusive world-wide licensing agreement for the distribution of the product with Clinigen from January 2021, PBL has pursued a strategy of obtaining Marketing Authorisations in its name in numerous territories.
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Erwinase®是一种成熟的全球产品,用于治疗急性淋巴细胞白血病(ALL),这是一种特别影响儿童的癌症。 自1985年在英国获得首个许可以来,Erwinase®在过去的36年中已在全球治疗了超过90,000名患者。 该产品具有良好的安全性特征,为许多国家的医疗保健专业人员所熟悉。
Erwinase® is an asparaginase enzyme derived from the bacterium 欧文氏菌chrysanthemi that is used as part of the treatment protocols in conjunction with radiotherapy or chemotherapy.
天冬酰胺是一种对细胞生长至关重要的氨基酸; 它由大多数细胞产生,但不是所有细胞。 ALL中突变的癌细胞依靠血液中循环的天冬酰胺生长。 l -天冬酰胺酶是一组酶,可以降低血液中循环的天冬酰胺水平,从而剥夺突变细胞的天冬酰胺并抑制它们的生长。
市场上有几种不同类型的l -天冬酰胺酶,每种都来自不同的细菌。 Patients receiving treatment with L-asparaginase derived from 大肠杆菌; who develop hypersensitivity to that form of the enzyme, may be able to continue treatment with Erwinase® as the enzymes are immunologically distinct. Antibodies targeting 大肠杆菌 derived L-Asparaginase have been shown not to cross-react with Erwinase®.